CORRELATION BETWEEN PLATELET MONO-AMINE OXIDASE ACTIVITY AND PLASMA PROLACTIN CONCENTRATIONS IN MAN

被引：36

作者：

KLEINMAN, JE

POTKIN, S

ROGOL, A

BUCHSBAUM, MS

MURPHY, DL

GILLIN, JC

NASRALLAH, HA

WYATT, RJ

机构：

[1] UNIV VIRGINIA,MED CTR,DEPT PEDIAT,CHARLOTTESVILLE,VA 22908

[2] NIMH,NEUROPHARMACOL LAB,BETHESDA,MD 20205

[3] NIMH,CLIN PSYCHOPHYSIOL LAB,BETHESDA,MD 20205

来源：

SCIENCE | 1979年 / 206卷 / 4417期

关键词：

D O I：

10.1126/science.504993

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Increases in plasma prolactin concentrations produced by α-methyl-p-tyrosine, a catecholamine synthesis inhibitor, varied inversely with baseline platelet monoamine oxidase activity in 12 patients with chronic schizophrenia. In normal volunteers with low monoamine oxidase activity and in unmedicated patients with chronic schizophrenia, plasma prolactin concentrations varied directly with platelet monoamine oxidase activity. No such relationship was found in normal subjects with high platelet monoamine oxidase activity. These data suggest that platelet monoamine oxidase activity reflects monoaminergic activity in the tubero-infundibular system, which in turn affects plasma prolactin concentrations. This relationship may be important in patients with low platelet monoamine oxidase activity, such as some chronic schizophrenics. Copyright © 1979 AAAS.

引用

页码：479 / 481

页数：3

共 32 条

[1]

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[2]

BELMAKER RH, 1974, ARCH GEN PSYCHIAT, V31, P553

[3]

BROWN JB, 1977, AM J PSYCHIAT, V134, P206

[4] BIOCHEMICAL HIGH-RISK PARADIGM - BEHAVIORAL AND FAMILIAL CORRELATES OF LOW PLATELET MONOAMINE-OXIDASE ACTIVITY [J].