TESTOSTERONE AND CYPROTERONE-ACETATE MODULATE PERIPHERAL BUT NOT CENTRAL BENZODIAZEPINE RECEPTORS IN RATS

被引:25
作者
AMIRI, Z
WEIZMAN, R
KATZ, Y
BURSTEIN, O
EDOUTE, Y
LOCHNER, A
GAVISH, M
机构
[1] TECHNION ISRAEL INST TECHNOL,FAC MED,DEPT PHARMACOL,POB 9649,IL-31096 HAIFA,ISRAEL
[2] TECHNION ISRAEL INST TECHNOL,FAC MED,RAPPAPORT FAMILY INST RES MED SCI,IL-31096 HAIFA,ISRAEL
[3] TECHNION ISRAEL INST TECHNOL,FAC MED,DEPT INTERNAL MED C,IL-31096 HAIFA,ISRAEL
[4] HASHARON HOSP,PETAH TIQWA,ISRAEL
[5] TEL AVIV UNIV,SACKLER SCH MED,TEL AVIV,ISRAEL
[6] UNIV STELLENBOSCH,FAC MED,DEPT MED PHYSIOL & BIOCHEM,TYGERBERG 7505,SOUTH AFRICA
关键词
TESTOSTERONE; CYPROTERONE; PERIPHERAL BENZODIAZEPINE RECEPTOR; CENTRAL BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE; PK-11195; FLUNITRAZEPAM;
D O I
10.1016/0006-8993(91)90243-O
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sixteen days of testosterone acetate (TA) treatment in male rats induced an increase in the densities of peripheral benzodiazepine receptors (PBR) in the adrenal and Cowper's glands and a decrease in PBR density in the testis. TA did not alter PBR density in the heart, cerebral cortex, or pituitary, or central benzodiazepine receptor (CBR) density in the cerebral cortex or hypothalamus. The antiandrogenic agent cyproterone acetate induced a decrease in PBR density in the testis, adrenal, and pituitary, but did not affect PBR density in Cowper's glands, heart, or cerebral cortex, or CBR density in the cerebral cortex or hypothalamus. In all of the above organs, affinity values did not change following the treatment with both agents. The receptoral changes may be relevant to the physiological and neurobehavioral effects of the chronic exogenous androgenic and antiandrogenic treatment.
引用
收藏
页码:155 / 158
页数:4
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