MACROLIDE BIOSYNTHESIS .6. MECHANISM OF POLYKETIDE CHAIN ELONGATION

被引：38

作者：

CANE, DE

PRABHAKARAN, PC

TAN, WT

OTT, WR

机构：

[1] Department of Chemistry, Brown University, Providence

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 40期

关键词：

D O I：

10.1016/0040-4039(91)80057-D

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Incorporation of the NAC thioester of (2S, 3R)-[3-H-2, 3-C-13]-2-methyl-3-hydroxypentanoic acid into both erythromycin A (9) and B (2) and nargenicin A1 (3) takes place without loss of deuterium.

引用

页码：5457 / 5460

页数：4

共 14 条

[1] MACROLIDE BIOSYNTHESIS .4. INTACT INCORPORATION OF A CHAIN-ELONGATION INTERMEDIATE INTO ERYTHROMYCIN
CANE, DE
YANG, CC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (04) : 1255 - 1257
[2] MACROLIDE BIOSYNTHESIS .2. ORIGIN OF THE CARBON SKELETON AND OXYGEN-ATOMS OF THE ERYTHROMYCINS
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HASLER, H
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LIANG, TC
[J]. TETRAHEDRON, 1983, 39 (21) : 3449 - 3455
[3] NARGENICIN BIOSYNTHESIS - LATE STAGE OXIDATIONS AND ABSOLUTE-CONFIGURATION
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YANG, CC
[J]. JOURNAL OF ANTIBIOTICS, 1985, 38 (03) : 423 - 426
[4] MACROLIDE BIOSYNTHESIS .5. INTACT INCORPORATION OF A CHAIN-ELONGATION INTERMEDIATE INTO NARGENICIN
CANE, DE
OTT, WR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (14) : 4840 - 4841
[5] BIOSYNTHETIC ORIGIN OF THE CARBON SKELETON AND OXYGEN-ATOMS OF NARGENICIN-A1
CANE, DE
YANG, CC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (03) : 784 - 787
[6] AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA
CORTES, J
HAYDOCK, SF
ROBERTS, GA
BEVITT, DJ
LEADLAY, PF
[J]. NATURE, 1990, 348 (6297) : 176 - 178
[7] MODULAR ORGANIZATION OF GENES REQUIRED FOR COMPLEX POLYKETIDE BIOSYNTHESIS
DONADIO, S
STAVER, MJ
MCALPINE, JB
SWANSON, SJ
KATZ, L
[J]. SCIENCE, 1991, 252 (5006) : 675 - 679
[8] BRANCHED-CHAIN FATTY-ACIDS PRODUCED BY MUTANTS OF STREPTOMYCES-FRADIAE, PUTATIVE PRECURSORS OF THE LACTONE RING OF TYLOSIN
HUBER, MLB
PASCHAL, JW
LEEDS, JP
KIRST, HA
WIND, JA
MILLER, FD
TURNER, JR
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (08) : 1535 - 1541
[9] KONOSHITA K, 1988, J CHEM SOC CHEM COMM, P943
[10] OMURA S, 1984, MACROLIDE ANTIBIOTIC, P199

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