LOBSTER TROPONIN-C - AMINO-ACID-SEQUENCES OF 3 ISOFORMS

被引：41

作者：

GARONE, L

THEIBERT, JL

MIEGEL, A

MAEDA, Y

MURPHY, C

COLLINS, JH

机构：

[1] UNIV MARYLAND,SCH MED,DEPT BIOL CHEM,660 W REDWOOD ST,BALTIMORE,MD 21201

[2] DESY,EUROPEAN MOLEC BIOL LAB,W-2000 HAMBURG 52,GERMANY

[3] UNIV MARYLAND,DEPT CHEM & BIOCHEM,CATONSVILLE,MD 21228

[4] UNIV MARYLAND,MARYLAND BIOTECHNOL INST,CTR MED BIOTECHNOL,BALTIMORE,MD 21201

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1991年 / 291卷 / 01期

关键词：

D O I：

10.1016/0003-9861(91)90108-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have determined the amino acid sequences of the three major isoforms of lobster troponin C, using protein chemistry methods. Each isoform contains 150 amino acid residues, with a calculated Mr of 17,000 ± 100. Sequence differences occur in all regions of the polypeptides, indicating that the isoforms are products of three different genes, rather than alternative transcripts of a single gene. Analysis of the sequences predicts that functional Ca2+-binding sites are present only in regions II and IV of four ancestral regions. © 1991.

引用

页码：89 / 91

页数：3

共 21 条

[1]

Collins J. H., 1976, SOC EXP BIOL S, V30, P303

[2] MYOSIN LIGHT-CHAINS AND TROPONIN-C - STRUCTURAL AND EVOLUTIONARY RELATIONSHIPS REVEALED BY AMINO-ACID-SEQUENCE COMPARISONS [J].