BACTERICIDAL ACTIVITY OF RAMOPLANIN AGAINST ANTIBIOTIC-RESISTANT ENTEROCOCCI

被引：39

作者：

JOHNSON, CC ^{[1
]}

TAYLOR, S ^{[1
]}

PITSAKIS, P ^{[1
]}

MAY, P ^{[1
]}

LEVISON, ME ^{[1
]}

机构：

[1] DEPT VET AFFAIRS MED CTR,PHILADELPHIA,PA 19104

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 10期

关键词：

D O I：

10.1128/AAC.36.10.2342

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ramoplanin, a new lipoglycodepsipeptide antibiotic, was uniformly active against 65 strains of enterococci, including strains highly resistant to vancomycin, penicillin, G, and gentamicin. MBCs were usually within a fourfold dilution of the MICs. In time-kill studies, ramoplanin alone demonstrated dose-dependent bactericidal activity against enterococcal strains that resisted killing by vancomycin or penicillin in combination with gentamicin.

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页码：2342 / 2345

页数：4

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