5-[(3-NITROPYRID-2-YL)AMINO]INDOLES - NOVEL SEROTONIN AGONISTS WITH SELECTIVITY FOR THE 5-HT1D RECEPTOR - VARIATION OF THE C3 SUBSTITUENT ON THE INDOLE TEMPLATE LEADS TO INCREASED 5-HT1D RECEPTOR SELECTIVITY

被引：39

作者：

MACOR, JE ^{[1
]}

BLANK, DH ^{[1
]}

FOX, CB ^{[1
]}

LEBEL, LA ^{[1
]}

NEWMAN, ME ^{[1
]}

POST, RJ ^{[1
]}

RYAN, K ^{[1
]}

SCHMIDT, AW ^{[1
]}

SCHULZ, DW ^{[1
]}

KOE, BK ^{[1
]}

机构：

[1] PFIZER INC,DIV CENT RES,DEPT NEUROSCI,GROTON,CT 06340

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 16期

关键词：

D O I：

10.1021/jm00042a003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：2509 / 2512

页数：4

共 18 条

[1] SEROTONIN RECEPTORS - CLINICAL IMPLICATIONS [J].

GLENNON, RA .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1990, 14 (01) :35-47

[2]

GLUCHOWSKI C, 1993, ANNU REP MED CHEM, V28, P29

[3] MOLECULAR-BIOLOGY OF THE 5-HT(1) RECEPTOR SUBFAMILY [J].

HARTIG, PR ;

ADHAM, N ;

ZGOMBICK, J ;

WEINSHANK, R ;

BRANCHEK, T .

DRUG DEVELOPMENT RESEARCH, 1992, 26 (03) :215-224

[4] (+/-) 3-AMINO-6-CARBOXAMIDO-1,2,3,4-TETRAHYDROCARBAZOLE - A CONFORMATIONALLY RESTRICTED ANALOG OF 5-CARBOXAMIDOTRYPTAMINE WITH SELECTIVITY FOR THE SEROTONIN 5-HT1D RECEPTOR [J].

KING, FD ;

BROWN, AM ;

GASTER, LM ;

KAUMANN, AJ ;

MEDHURST, AD ;

PARKER, SG ;

PARSONS, AA ;

PATCH, TL ;

RAVAL, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (13) :1918-1919

[5]

LEE WS, 1993, BRAIN RES, V626, P303

[6] SYNTHESIS AND SEROTONERGIC PHARMACOLOGY OF THE ENANTIOMERS OF 3-[(N-METHYLPYRROLIDIN-2-YL)METHYL]-5-METHOXY-1H-INDOLE - DISCOVERY OF STEREOGENIC DIFFERENTIATION IN THE AMINOETHYL SIDE-CHAIN OF THE NEUROTRANSMITTER SEROTONIN [J].

MACOR, JE ;

BLAKE, J ;

FOX, CB ;

JOHNSON, C ;

KOE, BK ;

LEBEL, LA ;

MORRONE, JM ;

RYAN, K ;

SCHMIDT, AW ;

SCHULZ, DW ;

ZORN, SH .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (23) :4503-4505

[7]

MACOR JE, 1990, HETEROCYCLES, V31, P1497

[8]

MACOR JE, 1990, HETEROCYCLES, V31, P805

[9] THE SYNTHESIS OF PYRANO[3,2-E]INDOLES AND PYRANO[2,3-F]INDOLES AS ROTATIONALLY RESTRICTED PHENOLIC ANALOGS OF THE NEUROTRANSMITTER SEROTONIN [J].

MACOR, JE ;

RYAN, K ;

NEWMAN, ME .

TETRAHEDRON, 1992, 48 (06) :1039-1052

[10] A SIMPLE SYNTHESIS OF 5-AMINO-3-(2-DIMETHYLAMINOETHYL)INDOLE [5-AMINO-N,N-DIMETHYLTRYPTAMINE] [J].

MACOR, JE ;

POST, R ;

RYAN, K .

SYNTHETIC COMMUNICATIONS, 1993, 23 (01) :65-72

← 1 2 →