MITOCHONDRIAL ATP SYNTHASE ALPHA-SUBUNIT GENE AMPLIFIED IN A RETINOBLASTOMA CELL-LINE MAPS TO CHROMOSOME-18

被引：7

作者：

BIE, WJ

SQUIRE, JA

FRASER, M

PATERSON, MC

GODBOUT, R

机构：

[1] CROSS CANC INST,MOLEC ONCOL PROGRAM,EDMONTON,AB T6G 1Z2,CANADA

[2] UNIV ALBERTA,DEPT ONCOL,EDMONTON,AB,CANADA

[3] UNIV TORONTO,HOSP SICK CHILDREN,DEPT PATHOL,TORONTO,ON M5G 1X8,CANADA

来源：

GENES CHROMOSOMES & CANCER | 1995年 / 14卷 / 01期

关键词：

D O I：

10.1002/gcc.2870140111

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The human retinoblastoma cell line Y79 has multiple copies of the MYCN gene and the DEAD box gene DDXI. Both genes have been mapped to chromosome band 2p24. A third gene, encoding the alpha-subunit of mitochondrial ATP synthase (ATPSA), is also amplified in Y79. Here we report that there are at least four human mitochondrial ATPSA-related genes located on four different chromosomes. The ATPSA gene that is amplified in Y79 originates from chromosome 18. In Y79, the amplified copies of both the ATPSA and the MYCN genes are located on a homogeneously staining region (HSR) at chromosome band 1p34. (C) 1995 Witey-Liss, Inc.

引用

页码：63 / 67

页数：5

共 23 条

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