THE EFFECT OF ALKOXY SUBSTITUENTS ON THE MUTAGENICITY OF SOME PHENYLENEDIAMINE-BASED DISAZO DYES

被引：8

作者：

ESANCY, JF

FREEMAN, HS

CLAXTON, LD

机构：

[1] N CAROLINA STATE UNIV,DEPT TEXT ENGN CHEM & SCI,RALEIGH,NC 27695

[2] US EPA,HLTH EFFECTS RES LAB,DIV GENET TOXICOL,RES TRIANGLE PK,NC 27711

来源：

MUTATION RESEARCH | 1990年 / 238卷 / 01期

关键词：

Alkoxy substituents; Disazo dyes; phenylenediamine-based; Phenylenediamine-based disaszo dyes; Salmonella/mammalian microsome assay;

D O I：

10.1016/0165-1110(90)90037-C

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

16 phenylenediamine-based disazo dyes were examined in the Salmonella/mammalian microsome assay with strains TA98, TA100 and TA1538. All of the dyes contain an alkoxy group ortho to one of the azo linkages. Increasing the size of this alkoxy substituent from 1 to 4 carbons led to a decrease in mutagenic activity in certain instances while no change was noted in other cases. Comparison of the mutagenicity of the disazo dyes with their potential reductive-cleavage products suggests that (1) the reductive-cleavage products are not solely responsible for the mutagenicity of the disazo dyes, and (2) significant reductive-cleavage of the disazo dyes is not taking place in the standard Salmonella assay. © 1990.

引用

页码：23 / 38

页数：16

共 21 条

[1] AN EMPIRICAL-APPROACH TO THE STATISTICAL-ANALYSIS OF MUTAGENESIS DATA FROM THE SALMONELLA TEST [J].