THEORETICAL-MODEL STUDY OF THE REACTIVITY OF BENZO(A)PYRENE DIOL EPOXIDE WITH THE AMINO-GROUPS OF THE NUCLEIC-ACID BASES

被引：11

作者：

LAVERY, R

PULLMAN, B

机构：

[1] Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique associé au C.N.R.S, Paris, F-75005

来源：

INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY | 1979年 / 16卷 / 01期

关键词：

D O I：

10.1002/qua.560160119

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A quantum‐mechanical model study, aided by classical potential calculations, of the formation of adducts between the candidate ultimate carcinogen benzo(a)pyrene diol epoxide and the amino groups of guanine, adenine, and cytosine is presented. An explanation for the preferential reactivity of guanine is proposed and conformational aspects of adduct formation are discussed for both nucleosides and B‐DNA. Copyright © 1979 John Wiley & Sons, Inc.

引用

页码：175 / 188

页数：14

共 26 条

[1] OPTIMIZED PARAMETERS FOR A-DNA AND B-DNA
ARNOTT, S
HUKINS, DWL
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1972, 47 (06) : 1504 - &
[2] VAN DER WAALS VOLUMES + RADII
BONDI, A
[J]. JOURNAL OF PHYSICAL CHEMISTRY, 1964, 68 (03) : 441 - +
[3] BROOKES P, POLYCYCLIC HYDROCARB
[4] THEORETICAL EVALUATION OF INTERMOLECULAR INTERACTION ENERGY OF A CRYSTAL - APPLICATION TO ANALYSIS OF CRYSTAL GEOMETRY
CAILLET, J
CLAVERIE, P
[J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1975, 31 (JUL1): : 448 - 461
[5] HEHRE WJ, 1973, QCPE70 IND U GAUSS
[6] CARBONIUM-ION AS ULTIMATE CARCINOGEN OF POLYCYCLIC AROMATIC-HYDROCARBONS
HULBERT, PB
[J]. NATURE, 1975, 256 (5513) : 146 - 148
[7] DNA AND RNA ADDUCTS FORMED IN HAMSTER EMBRYO CELL-CULTURES EXPOSED TO BENZO[A]PYRENE
IVANOVIC, V
GEACINTOV, NE
YAMASAKI, H
WEINSTEIN, IB
[J]. BIOCHEMISTRY, 1978, 17 (09) : 1597 - 1603
[8] NUCLEOSIDE ADDUCTS FROM INVITRO REACTION OF BENZO[A]PYRENE-7,8-DIHYDRODIOL 9,10-OXIDE OR BENZO[A]PYRENE 4,5-OXIDE WITH NUCLEIC-ACIDS
JENNETTE, KW
JEFFREY, AM
BLOBSTEIN, SH
BELAND, FA
HARVEY, RG
WEINSTEIN, IB
[J]. BIOCHEMISTRY, 1977, 16 (05) : 932 - 938
[9] JERINA DM, 1977, MICROSOMES DRUG OXID
[10] JERINA DM, 1976, IN VITRO METABOLIC A

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