THROMBOSPONDIN BINDS NORMALLY TO GLYCOPROTEIN-IIIB DEFICIENT PLATELETS

被引：37

作者：

KEHREL, B

KRONENBERG, A

SCHWIPPERT, B

NIESINGBRESCH, D

NIEHUES, U

TSCHOPE, D

VANDELOO, J

CLEMETSON, KJ

机构：

[1] UNIV DUSSELDORF, DIABET RES INST, W-4000 DUSSELDORF 1, GERMANY

[2] UNIV BERN, THEODOR KOCHER INST, CH-3000 BERN, SWITZERLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 179卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91915-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycoprotein IIIb (GPIV, CD36) has been proposed as the platelet receptor for thrombospondin (TSP). We found two healthy blood donors, whose platelets were shown to be GPIIIb deficient. These platelets expressed endogeneous TSP as control platelets and their binding capacity for exogeneous TSP was the same. These results indicate that GPIIIb is not the major TSP receptor on platelets. However, it is not yet possible to exclude that in GPIIIb-deficient platelets other proteins may substitute for GPIIIb in TSP binding. © 1991.

引用

页码：985 / 991

页数：7

共 18 条

[1] ISOLATION OF THE THROMBOSPONDIN MEMBRANE-RECEPTOR [J].