DOUBLE-BLIND-STUDY OF GABAPENTIN IN THE TREATMENT OF PARTIAL SEIZURES

被引：153

作者：

SIVENIUS, J ^{[1
]}

KALVIAINEN, R ^{[1
]}

YLINEN, A ^{[1
]}

RIEKKINEN, P ^{[1
]}

机构：

[1] UNIV KUOPIO, DEPT NEUROL, SF-70211 KUOPIO 21, FINLAND

来源：

EPILEPSIA | 1991年 / 32卷 / 04期

关键词：

EPILEPSY; ANTICONVULSANTS; GABEPENTIN; DRUG-INDUCED ABNORMALITIES;

D O I：

10.1111/j.1528-1157.1991.tb04689.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Forty-three patients completed a double-blind, placebo-controlled study of Gabapentin (GBP) as add-on therapy in partial and secondarily generalized seizures. All patients were followed for an initial 3-month baseline period, after which they were randomly allocated to receive either a placebo or 900 or 1,200 mg/day GBP for 3 months. A statistically significant difference in seizure frequency from the baseline to the treatment phase was noted between patients receiving placebo and GBP 1,200 mg, in whom seizure frequencly decreased 57%. The GBP dosage of 900 mg appeared to be ineffective. A close relationship was observed between the serum GBP concentrations and the GBP dosage based on the seizure frequency. Serum GBP concentrations > 2-mu-g/ml resulted in a lower frequency of seizures. The adverse effects were minor and consisted mainly of transient drowsiness. GBP appears to be effective in the treatment of partial epileptic seizures in a dosage-related manner.

引用

页码：539 / 542

页数：4