AN INTEGRATED APPROACH FOR THE COMPUTER-ASSISTED TREATMENT OF DIABETIC-PATIENTS ON INSULIN

被引：13

作者：

LEHMANN, ED

DEUTSCH, T

ROUDSARI, AV

CARSON, ER

BENN, JJ

SONKSEN, PH

机构：

[1] Department of Endocrinology, Chemical Pathology and Medicine, United Medical and Dental Schools, St. Thoma's Hospital, London

[2] Computer Centre, Semmelweis University of Medicine, Budapest

[3] Centre for Measurement and Information in Medicine, Department of Systems Science, City University, London

来源：

MEDICAL INFORMATICS | 1992年 / 17卷 / 02期

关键词：

KNOWLEDGE-BASED SYSTEM; INSULIN ADVISORY THERAPY; DIABETES-MELLITUS; DYNAMIC SIMULATION;

D O I：

10.3109/14639239209085014

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

A prototype computer system has been developed to provide advice on the day-to-day adjustment of carbohydrate intake and insulin regimen in the insulin-dependent diabetic patient. The system also produces a 24-h simulation of the patient's blood glucose profile based on these adjustments. Advice is generated by a qualitative knowledge-based system which suggests what the next step in improving glycaemic control might be for a given patient, e.g. 'decrease morning short-acting insulin by 2 units'. The quantitative simulator module contains two different mathematical models. The first is a non-linear model in differential equation form which consists of a one-compartment glucose model linked to a model with free and bound insulin compartments. This physiological model is solved by a general-purpose simulation engine. The second is a linear systems model which uses a transfer function to describe the insulin input blood glucose response relationship for individual diabetic patients. Results of a preliminary medical validation are presented.

引用

页码：105 / 123

页数：19

共 32 条

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