INVESTIGATION OF AN OUTBREAK OF BLOODY DIARRHEA - ASSOCIATION WITH ENDOSCOPIC CLEANING SOLUTION AND DEMONSTRATION OF LESIONS IN AN ANIMAL-MODEL

被引：41

作者：

DURANTE, L

ZULTY, JC

ISRAEL, E

POWERS, PJ

RUSSELL, RG

QIZILBASH, AH

MORRIS, JG

机构：

[1] UNIV MARYLAND, SCH MED, DEPT MED, DIV GEOG MED, 10 S PINE ST, BALTIMORE, MD 21201 USA

[2] UNIV MARYLAND, SCH MED, PROGRAM COMPARAT MED, BALTIMORE, MD 21201 USA

[3] UNIV MARYLAND, SCH MED, DEPT PATHOL, BALTIMORE, MD 21201 USA

[4] MARYLAND DEPT HLTH & METN HYG, EPIDEMIOL & DIS CONTROL PROGRAM, BALTIMORE, MD USA

[5] DEPT VET AFFAIRS MED CTR, BALTIMORE, MD USA

[6] N YORK GEN HOSP, N YORK, ONTARIO, CANADA

来源：

AMERICAN JOURNAL OF MEDICINE | 1992年 / 92卷 / 05期

关键词：

D O I：

10.1016/0002-9343(92)90743-U

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OUTBREAK INVESTIGATION: An outbreak of diarrhea, bloody diarrhea, and abdominal cramps occurred among persons undergoing flexible sigmoidoscopy at a branch clinic of a local health center. Illness was associated with use of sigmoidoscopes cleaned by one clinic assistant and appeared to be caused by 2% glutaraldehyde disinfectant solution left in the instruments after cleaning. ANIMAL STUDIES: In subsequent animal studies, colonic instillation of 2% glutaraldehyde solutions caused bloody diarrhea and a distinctive pattern of mucosal damage; similar changes were seen in a review of pathologic samples from other human cases of glutaraldehyde disinfectant-associated diarrhea. CONCLUSION: Our data indicate that improper endoscopic reprocessing can result in serious illness and underscore the importance of adequate training and quality control in this area.

引用

页码：476 / 480

页数：5

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