SEQUENCE COMPARISON BETWEEN THE PHOSPHOPROTEIN MESSENGER-RNAS OF HUMAN AND BOVINE RESPIRATORY SYNCYTIAL VIRUSES IDENTIFIES A DIVERGENT DOMAIN IN THE PREDICTED PROTEIN

被引：24

作者：

MALLIPEDDI, SK ^{[1
]}

SAMAL, SK ^{[1
]}

机构：

[1] UNIV MARYLAND, COLL VET MED, College Pk, MD 20742 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-9-2441

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The nucleotide and deduced amino acid sequences of the phosphoprotein (P) mRNA of bovine respiratory syncytial virus (BRSV) strain A51908 have been determined. The P mRNA is 860 nucleotides long with a single large open reading frame and the encoded polypeptide is 241 amino acids long. Comparison with the corresponding sequences of human respiratory syncytial virus (HRSV) subgroups A and B revealed 72 to 74 % identity at the nucleotide level, and 81 % at the amino acid level. The P protein contains a single divergent domain (37 % amino acid identity) flanked by highly conserved domains (87 % amino acid identity). The 3' end non-coding region is 47 nucleotides shorter than the corresponding region of HRSV. Comparison of the P mRNA sequences of two strains of BRSV (A51908 and FS-1) showed that there was extensive sequence identity at both the nucleotide (97 %) and amino acid (97.9 %) levels.

引用

页码：2441 / 2444

页数：4

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