FIMBRIAE OF BRANHAMELLA-CATARRHALIS AS POSSIBLE MEDIATORS OF ADHERENCE TO PHARYNGEAL EPITHELIAL-CELLS

被引：13

作者：

AHMED, K

机构：

[1] Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University

来源：

APMIS | 1992年 / 100卷 / 12期

关键词：

FIMBRIAE; ADHESIN; B-CATARRHALIS;

D O I：

10.1111/j.1699-0463.1992.tb04042.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study attempted to elucidate the role of fimbriae in the adherence of B. catarrhalis to human oropharyngeal epithelial cells. Antifimbrial immune serum was prepared by immunization of rabbit with whole fimbriated bacteria, and adsorption of the serum with a nonfimbriated B. catarrhalis strain. After pretreatment with the antifimbrial antiserum, the adherence of fimbriated B. catarrhalis to human epithelial cells was significantly decreased (p < 0.05). The adherence was also significantly (p < 0.001) decreased by trypsin treatment. Electron microscopy revealed destruction of fimbriae after trypsin treatment. These observations suggest that fimbriae are involved in the adherence of B. catarrhalis to epithelial cells.

引用

页码：1066 / 1072

页数：7

共 22 条

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