AGE-RELATED-CHANGES IN THE MOLECULAR-PROPERTIES OF VITREOUS COLLAGEN

被引：17

作者：

AKIBA, J

UENO, N

CHAKRABARTI, B

机构：

[1] HARVARD UNIV,SCH MED,SCHEPENS EYE RES INST,DEPT OPHTHALMOL,20 STANIFORD ST,BOSTON,MA 02114

[2] ASAHIKAWA MED COLL,DEPT OPHTHALMOL,ASAHIKAWA 07811,JAPAN

来源：

CURRENT EYE RESEARCH | 1993年 / 12卷 / 10期

关键词：

D O I：

10.3109/02713689309020402

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

To understand the molecular events underlying rheological vitreous changes, age-related changes in the molecular properties of bovine and human vitreous collagen were monitored by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The adult bovine vitreous showed an increase in the highmolecular-weight components of the collagen compared with the young samples. In addition, the apparent molecular size of the alpha-chain of the adult type II collagen was slightly larger than that of the young samples. The same tendency also was observed in human vitreous. The increase of high-molecular-weight components of the vitreous collagen could be attributed to intermolecular cross-links of the peptide chains.

引用

页码：951 / 954

页数：4

共 30 条

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[2]

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