IN-VIVO EFFECT OF PREDNISOLONE ON RELEASE OF LEUKOTRIENE C4 IN EOSINOPHILS OBTAINED FROM ASTHMATIC-PATIENTS

被引：6

作者：

SHINDO, K

HIRAI, Y

KOIDE, K

SUMITOMO, M

FUKUMURA, M

机构：

[1] First Department of Internal Medicine, Yokohama City University, School of Medicine, Kanazawa-ku, Yokohama 236, 3-9, Fukuura

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 214卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2367

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the release of leukotriene C4 from eosinophils of asthmatic patients who were treated with or without intravenous prednisolone. The mean level of LTC4 in the supernatant of A23187-stimulated eosinophils obtained from asthmatic patients during an attack was significantly lower with intravenous prednisolone than without prednisolone treatment. Findings suggest that intravenous prednisolone inhibits the release of LTC4 from the eosinophils of asthmatic patients by acting on these cells in vivo. (C) 1995 Academic Press, Inc.

引用

页码：869 / 874

页数：6

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