EFFECTS OF DESICCATED THYROID PREDNISOLONE AND CHLOROQUINE ON GOITER AND ANTIBODY TITER IN CHRONIC THYROIDITIS

被引：19

作者：

ITO, S

TAMURA, T

NISHIKAWA, M

机构：

[1] Second Department of Internal Medicine, Osaka University Medical School, Osaka

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1968年 / 17卷 / 04期

关键词：

D O I：

10.1016/0026-0495(68)90100-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This paper describes the effects of desiccated thyroid, prednisolone and chloroquine in patients with chronic thyroiditis. The clinical course of patients was studied with special attention to changes in goiter size and serum antibody titer. The changes in the complement fixing capacity of aggregated γ-globulin under the influence of these drugs were studied in vitro. Prednisolone treatment caused a decrease in goiter size and hardness and in the titer of complement fixing antibody. Prednisolone and chloroquine treatments caused a change in serum complement but not in the tanned red cell agglutination titer. Chloroquine caused a moderate decrease in the complement fixing antibody titer and a marked decrease in the complement fixing capacity of aggregated γ-globulin in vitro. In vitro studies demonstrated a competition between complement and chloroquine for the complement fixation sites on aggregated γ-globulin. Desiccated thyroid did not appear to play a significant immunochemical role but, of course, did help maintain a normal metabolic state. These results form the basis for a combined use of these drugs in the therapy of chronic thyroiditis. © 1968.

引用

页码：317 / +

页数：1

共 37 条

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[2]

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