HISTOPATHOGENESIS OF SKIN AND SUBCUTANEOUS INJURY INDUCED BY ADRIAMYCIN

被引：38

作者：

LUEDKE, DW

KENNEDY, PS

RIETSCHEL, RL

机构：

[1] BROOKE ARMY MED CTR,DEPT MED,ONCOL SERV,FT SAM HOUSTON,TX 78234

[2] BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,FT SAM HOUSTON,TX 78234

来源：

PLASTIC AND RECONSTRUCTIVE SURGERY | 1979年 / 63卷 / 04期

关键词：

D O I：

10.1097/00006534-197904000-00003

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Extravasation of Adriamycin from an intravenous needle or catheter can produce a progressive skin necrosis and deep painful ulceration. The pathological changes which result in this ulceration were studied in a rabbit model. The earliest changes include vascular obliteration and necrobiosis of collagen. At no point were inflammatory cells found to play a primary role. © 1979 American Society of Plastic Surgeons.

引用

页码：463 / 465

页数：3