INOTROPIC ACTIVITIES OF IMIDAZOPYRIDINES

被引：12

作者：

BARRACLOUGH, P ^{[1
]}

BLACK, JW ^{[1
]}

CAMBRIDGE, D ^{[1
]}

GERSKOWITCH, VP ^{[1
]}

HULL, RAD ^{[1
]}

LYER, R ^{[1
]}

KING, WR ^{[1
]}

KNEEN, CO ^{[1
]}

NOBBS, MS ^{[1
]}

SHAH, GP ^{[1
]}

SMITH, S ^{[1
]}

VINE, SJ ^{[1
]}

WHITING, MV ^{[1
]}

机构：

[1] WELLCOME RES LABS,DEPT PHARMACOL,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

ARCHIV DER PHARMAZIE | 1990年 / 323卷 / 08期

关键词：

D O I：

10.1002/ardp.19903230811

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2‐substituted 1H‐imidazo[4,5‐b]pyridines and the isomeric 1H‐imidazo[4,5‐c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H‐imidazo‐[4,5‐b] derivatives were found to be consistently more potent than their isomers in the [4,5‐c] series in isolated guinea pig papillary muscle preparations. Structure‐activity relationships and the species‐dependence of inotropic potencies are discussed. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：501 / 505

页数：5

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