5-HT-1A RECEPTOR-MEDIATED EFFECTS OF ANTIDEPRESSANTS

被引：37

作者：

NEWMAN, ME

LERER, B

SHAPIRA, B

机构：

[1] EZRATH NASHIM HERZOG HOSP, DEPRESS TREATMENT UNIT, JERUSALEM, ISRAEL

[2] HADASSAH UNIV HOSP, DEPT PSYCHIAT, BIOL PSYCHIAT LAB, IL-91120 JERUSALEM, ISRAEL

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1993年 / 17卷 / 01期

关键词：

ADENYLATE CYCLASE; ANTIDEPRESSANT; RECEPTOR; SEROTONIN;

D O I：

10.1016/0278-5846(93)90031-M

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Antidepressant (AD) drugs in general induce subsensitivity of behavioural functions associated with activation of 5-HT-1a receptors in animals. 2. Electrophysiological studies in animals in general indicate increased serotonergic transmission after AD administration, mediated partly by increased functioning of post-synaptic 5-HT-1a receptors in the hippocampus. 3. Binding studies have in general shown no change in 5-HT-1a receptor number either pre-or post-synaptically, while results of second messenger studies (inhibition of adenylate cyclase) indicate subsensitivity after AD administration. 4. Human studies also indicate subsensitivity of 5-HT-1a receptors after ADs.

引用

页码：1 / 19

页数：19

共 63 条

[1]

AMSTERDAM JD, 1987, CURR THER RES CLIN E, V41, P185

[2] A-G PROTEIN COUPLES SEROTONIN AND GABA-B RECEPTORS TO THE SAME CHANNELS IN HIPPOCAMPUS [J].