HOW UNIQUE ARE PATHOGENIC ANTI-DNA AUTOANTIBODY V-REGIONS

被引：8

作者：

LOGTENBERG, T

机构：

[1] Department of Immunology, University Hospital Utrecht, Medical School, 3584 CX Utrecht, Room F03.821

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 06期

关键词：

D O I：

10.1016/0952-7915(94)90014-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Unique characteristics of the molecular structure of V regions encoding pathogenic anti-DNA autoantibodies have become apparent upon comparison of a large number of nucleotide sequences encoding this autospecificity. Moreover, the generation of transgenic animals expressing V regions encoding anti-DNA autoantibodies has shed light on the tolerizing mechanisms that regulate B cells producing antibodies against DNA.

引用

收藏

页码：921 / 925

页数：5

相关论文

共 28 条

[1] HUMAN LUPUS ANTI-DNA AUTOANTIBODIES UNDERGO ESSENTIALLY PRIMARY V-KAPPA GENE REARRANGEMENTS [J].

BENSIMON, C ;

CHASTAGNER, P ;

ZOUALI, M .

EMBO JOURNAL, 1994, 13 (13) :2951-2962

[2]

CHEN C, 1994, J IMMUNOL, V152, P1970

[3] MOLECULAR CHARACTERIZATION OF A SOMATICALLY MUTATED ANTI-DNA ANTIBODY BEARING 2 SYSTEMIC LUPUS ERYTHEMATOSUS-RELATED IDIOTYPES [J].

DAVIDSON, A ;

MANHEIMERLORY, A ;

ARANOW, C ;

PETERSON, R ;

HANNIGAN, N ;

DIAMOND, B .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (05) :1401-1409

[4] SOMATIC DIVERSIFICATION IN THE HEAVY-CHAIN VARIABLE REGION GENES EXPRESSED BY HUMAN AUTOANTIBODIES BEARING A LUPUS-ASSOCIATED NEPHRITOGENIC - ANTI-DNA IDIOTYPE [J].

DEMAISON, C ;

CHASTAGNER, P ;

THEZE, J ;

ZOUALI, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (02) :514-518

[5]

EILAT D, 1988, J IMMUNOL, V141, P1745

[6] EXPRESSION OF ANTI-DNA IMMUNOGLOBULIN TRANSGENES IN NON-AUTOIMMUNE MICE [J].

ERIKSON, J ;

RADIC, MZ ;

CAMPER, SA ;

HARDY, RR ;

CARMACK, C ;

WEIGERT, M .

NATURE, 1991, 349 (6307) :331-334

[7]

GANGEMI RMR, 1993, J IMMUNOL, V151, P4660

[8] RECEPTOR EDITING - AN APPROACH BY AUTOREACTIVE B-CELLS TO ESCAPE TOLERANCE [J].

GAY, D ;

SAUNDERS, T ;

CAMPER, S ;

WEIGERT, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (04) :999-1008

[9] ISOLATION OF HIGH-AFFINITY HUMAN-ANTIBODIES DIRECTLY FROM LARGE SYNTHETIC REPERTOIRES [J].

GRIFFITHS, AD ;

WILLIAMS, SC ;

HARTLEY, O ;

TOMLINSON, IM ;

WATERHOUSE, P ;

CROSBY, WL ;

KONTERMANN, RE ;

JONES, PT ;

LOW, NM ;

ALLISON, TJ ;

PROSPERO, TD ;

HOOGENBOOM, HR ;

NISSIM, A ;

COX, JPL ;

HARRISON, JL ;

ZACCOLO, M ;

GHERARDI, E ;

WINTER, G .

EMBO JOURNAL, 1994, 13 (14) :3245-3260

[10]

HIRABAYASHI Y, 1993, SCAND J IMMUNOL, V37, P533