BODY DISTRIBUTION AND ENDOCRINE TOXICITY OF HEXACHLOROBENZENE (HCB) IN THE FEMALE RAT

被引:27
作者
FOSTER, WG
PENTICK, JA
MCMAHON, A
LECAVALIER, PR
机构
[1] Environmental Health Centre, Health and Welfare Canada, Ottawa, Ontario
关键词
HEXACHLOROBENZENE; ESTRADIOL; PROGESTERONE; T3; T4; CORTISOL;
D O I
10.1002/jat.2550130203
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Hexachlorobenzene (HCB) residue levels in dosed rats (50.0 mg kg-1 body wt. day-1, n = 9) were significantly (P < 0.05) greater in the periovarian fat compared to the thyroid gland. Hexachlorobenzene residue levels were significantly (P < 0.05) greater in the thyroid versus the adrenal and ovary. Ovarian HCB residue levels were greater than those found in the thymus, liver and lung. Serum thyroxin (T4) and the free T4 index (FTI) were significantly (P < 0.05) suppressed in HCB-treated rats compared to the control group (n = 8). In contrast, no significant differences in serum concentrations of oestradiol (E2), progesterone (P4) or percentage triiodothyronine uptake (%T3) were observed, thus suggesting an HCB-induced hypothyroid-like state. In a second experiment, adult female Sprague Dawley rats (n = 16) were dosed as above and superovulated with pregnant mare serum gonadotrophin (PMSG, 10 IU s.c.) and human chorionic gonadotrophin (hCG, 20 IU s.c.). Circulating levels of P4 were significantly (P < 0.05) elevated compared to the control group (n = 8). The %T3 uptake and serum T4 levels were significantly (P = 0.05) suppressed compared to controls. Hexachlorobenzene treatment had no effect on circulating levels of E2 or on the FTI. These results suggest that HCB-induced changes found in the spontaneously cycling rat are augmented by ovulation induction strategies. We also conclude that HCB concentrates in the endocrine tissues in addition to the fat.
引用
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页码:79 / 83
页数:5
相关论文
共 30 条
[1]  
BABINEAU KA, 1991, J SUBMICR CYTOL PATH, V23, P457
[2]  
BAUKLOH V, 1987, ANN NY ACAD SCI, V442, P240
[3]   COMPARATIVE TOXICITY OF 1,2,3,4-TETRACHLOROBENZENE, 1,2,4,5-TETRACHLOROBENZENE, AND 1,2,3,5-TETRACHLOROBENZENE IN THE RAT - RESULTS OF ACUTE AND SUBACUTE STUDIES [J].
CHU, I ;
VILLENEUVE, D ;
SECOURS, V ;
VALLI, VE .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1983, 11 (4-6) :663-677
[4]   HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE AND PITUITARY AND PLASMA FSH AND PROLACTIN DURING PHOTOSTIMULATION AND PHOTOREFRACTORINESS IN INTACT AND THYROIDECTOMIZED STARLINGS (STURNUS, VULGARIS) [J].
DAWSON, A ;
FOLLETT, BK ;
GOLDSMITH, AR ;
NICHOLLS, TJ .
JOURNAL OF ENDOCRINOLOGY, 1985, 105 (01) :71-77
[5]   THYROID-FUNCTION AND THYROXINE METABOLISM IN HEXACHLOROBENZENE-INDUCED PORPHYRIA [J].
DEPISAREV, DLK ;
DEMOLINA, MDR ;
DEVIALE, LCSM .
BIOCHEMICAL PHARMACOLOGY, 1990, 39 (05) :817-825
[6]   HYPOTHYROIDISM AFFECTS REPRODUCTIVE REFRACTORINESS AND THE SEASONAL ESTROUS PERIOD IN WELSH MOUNTAIN EWES [J].
FOLLETT, BK ;
POTTS, C .
JOURNAL OF ENDOCRINOLOGY, 1990, 127 (01) :103-109
[7]   OVARIAN TOXICITY OF HEXACHLOROBENZENE (HCB) IN THE SUPEROVULATED FEMALE RAT [J].
FOSTER, WG ;
PENTICK, JA ;
MCMAHON, A ;
LECAVALIER, PR .
JOURNAL OF BIOCHEMICAL TOXICOLOGY, 1992, 7 (01) :1-4
[8]   HEXACHLOROBENZENE (HCB) SUPPRESSES CIRCULATING PROGESTERONE CONCENTRATIONS DURING THE LUTEAL PHASE IN THE CYNOMOLGUS MONKEY [J].
FOSTER, WG ;
MCMAHON, A ;
VILLENEUVE, DC ;
JARRELL, JF .
JOURNAL OF APPLIED TOXICOLOGY, 1992, 12 (01) :13-17
[9]   PROLONGED EXPOSURE TO WOOD PRESERVATIVES INDUCES ENDOCRINE AND IMMUNOLOGICAL DISORDERS IN WOMEN [J].
GERHARD, I ;
DERNER, M ;
RUNNEBAUM, B .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1991, 165 (02) :487-488
[10]   EFFECT OF HEXACHLOROBENZENE ON REPRODUCTION IN RAT [J].
GRANT, DL ;
PHILLIPS, WEJ ;
HATINA, GV .
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1977, 5 (02) :207-216