AMYOTROPHIC-LATERAL-SCLEROSIS

被引：8

作者：

EISEN, A

机构：

[1] The Neuromuscular Diseases Unit, The Vancouver General Hospital and the University of British Columbia

来源：

INTERNAL MEDICINE | 1995年 / 34卷 / 09期

关键词：

AGING; NEURODEGENERATION; EXCITOTOXICITY; APOPTOSIS; COMBINATION THERAPY;

D O I：

10.2169/internalmedicine.34.824

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The final cascade of amyotrophic lateral sclerosis (ALS) coincides with the onset of clinical neurological deficits and involves multifactorial interactive mechanisms, These terminal events include excitotoxicity, free radical accumulation and possibly immunological disturbances. They are probably predated by months or years by thus far unidentified triggers, Selective vulnerability of the corticomotneuronal system in ALS is likely due to degradation of several gene products essential to transmitter, receptor and nerve growth factor maintenance specific to this functional system, Therapeutic strategies involve neuroprotection, symptomatic and combination neuronal therapy targeted to the final cascade of ALS.

引用

页码：824 / 832

页数：9

共 93 条

[1]

Charcot J.M., Sclerose des cordons lateraux de la moelle epinere chez femme hysterique atteinte de contracture peranemte des quatre membres, Bull Soc Med Hop, 2, (1965)

[2]

Lillienfeld D.E., Chan E., Ehland J., Et al., Rising mortiality from motoneuron disease in the USA, Lancet, 1, (1989)

[3]

Pringle C.E., Hudson A.J., Munoz D.G., Et al., Primary lateral sclerosis, Brain, 115, (1992)

[4]

Eisen A., Kim S., Pant B., Amyotrophic lateral sclerosis (ALS): a phylogenetic disease of the corticomotoneuron?, Muscle Nerve, 15, (1992)

[5]

Rowland L.P., Sherman W.H., Latov N., Et al., Amyotrophic lateral sclerosis and lymphoma: bone marrow examination and other diagnostic tests, Neurology, 42, (1992)

[6]

Younger D.S., Rowland L.P., Latov N., Et al., Lymphoma, motor neuron diseases and amyotrophic lateral sclerosis, Ann Neurol, 29, (1991)

[7]

Parry G.J., Sumner A.J., Multifocal motor neuropathy, Neurologic Clinics, 10, (1992)

[8]

Eisen A., Calne D.B., Amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease: Phylogenetic disorders of the human neocortex sharing many characteristics, Can J Neurol Sci, 19, (1992)

[9]

Eisen A., Amyotrophic lateral sclerosis is a multifactorial disease, Muscle & Nerve, 18, (1995)

[10]

Eisen A., Krieger C., Pathogenetic mechanisms in amyotrophic lateral sclerosis, Can J Neurol Sci, 20, (1993)

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