ANTINEURONAL ANTIBODIES IN ACUTE CEREBELLAR-ATAXIA FOLLOWING EPSTEIN-BARR-VIRUS INFECTION

被引:53
作者
ITO, H
SAYAMA, S
IRIE, S
KANAZAWA, N
SAITO, T
KOWA, H
HAGA, S
IKEDA, K
机构
[1] KITASATO UNIV,EAST HOSP,SCH MED,DIV RES,SAGAMIHARA,KANAGAWA 228,JAPAN
[2] PSYCHIAT RES INST TOKYO,TOKYO 156,JAPAN
关键词
D O I
10.1212/WNL.44.8.1506
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A 29-year-old man developed acute cerebellar ataxia following Epstein-Barr virus infection. Serum IgG and IgM antibodies reacted with both nuclear and cytoplasmic elements of neurons. Western blot revealed IgG binding to the 34- and 29-kd bands and IgM binding to the 34-, 37-, and 29-kd bands. The IgM reactivity gradually reduced. There was no identifiable neoplasm and the ataxia gradually improved. These findings suggest a role for autoimmune mechanisms in the pathogenesis of acute cerebellar ataxia.
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页码:1506 / 1507
页数:2
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