ACTION OF DRUG PRENYLAMINE (SEGONTIN) ON EXPLORATORY ACTIVITY IN STRAINS OF RATS SELECTIVELY BRED FOR DIFFERENCES IN EMOTIONALITY

The action of 20 mg/kg, i.p. of the drug prenylamine (Segontin) upon two forms of exploratory activity was examined in strains of rats selectively bred for differences in emotionality. The drug significantly depressed ambulation in an Open Field arena compared to placebo and although not apparently related to a strain specific action of the drug, this depression was greater in the more emotional Reactive strain. On the rearing frequency the depressive effect was not statistically significant and, further, no strain differences were revealed in this situation. © 1968 Springer-Verlag.