A STEREOSELECTIVE SYNTHESIS OF CYCLOHEXYLNORSTATINE, THE KEY COMPONENT OF A RENIN INHIBITOR

被引：55

作者：

MATSUMOTO, T

KOBAYASHI, Y

TAKEMOTO, Y

ITO, Y

KAMIJO, T

HARADA, H

TERASHIMA, S

机构：

[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN

[2] KISSEI PHARMACEUT CO LTD,CENT RES LABS,NAGANO 399,JAPAN

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(00)97574-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title synthesis could be accomplished by employing the novel addition reaction of a Grignard reagent with an imine in the presence of cerium(III) chloride. © 1990.

引用

收藏

页码：4175 / 4176

页数：2

相关论文

共 11 条

[1] HARADA H, 1989, CHEM PHARM BULL, V37, P2570
[2] DESIGN AND SYNTHESIS OF AN ORALLY POTENT HUMAN RENIN INHIBITOR CONTAINING A NOVEL AMINO-ACID, CYCLOHEXYLNORSTATINE
IIZUKA, K
KAMIJO, T
HARADA, H
AKAHANE, K
KUBOTA, T
UMEYAMA, H
KISO, Y
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (21) : 1678 - 1680
[3] IIZUKA K, 1987, Patent No. 234071
[4] RECENT PROGRESS IN ORGANIC-SYNTHESIS WITH LANTHANOIDS
IMAMOTO, T
[J]. JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1988, 46 (06) : 540 - 552
[5] REACTIONS OF CARBONYL-COMPOUNDS WITH GRIGNARD-REAGENTS IN THE PRESENCE OF CERIUM CHLORIDE
IMAMOTO, T
TAKIYAMA, N
NAKAMURA, K
HATAJIMA, T
KAMIYA, Y
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (12) : 4392 - 4398
[6] ITO Y, 1990, HETEROCYCLES, V30, P299
[7] KAMIJO T, 1989, Patent No. 1172365
[8] KOBAYASHI Y, IN PRESS TETRAHEDRON
[9] AN EXPEDITIOUS SYNTHESIS OF THE (2R,3S)-3-AMINO-2-HYDROXYCARBOXYLIC AND (2S,3R)-3-AMINO-2-HYDROXYCARBOXYLIC ACIDS, THE KEY COMPONENTS OF A RENIN INHIBITOR AND BESTATIN, FROM (S)-PHENYLALANINE AND (R)-PHENYLALANINE
MATSUDA, F
MATSUMOTO, T
OHSAKI, M
ITO, Y
TERASHIMA, S
[J]. CHEMISTRY LETTERS, 1990, (05) : 723 - 724
[10] 4-O-BENZYL-2,3-O-ISOPROPYLIDENE-L-THREOSE - A NEW AND USEFUL BUILDING BLOCK FOR THE SYNTHESES OF L-SUGARS
MUKAIYAMA, T
SUZUKI, K
YAMADA, T
[J]. CHEMISTRY LETTERS, 1982, (06) : 929 - 932