HALOTHANE HEPATOTOXICITY AND FLUORIDE PRODUCTION IN MICE AND RATS

被引：12

作者：

GORSKY, BH ^{[1
]}

CASCORBI, HF ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV, SCH MED, DEPT ANESTHESIA, CLEVELAND, OH 44106 USA

来源：

ANESTHESIOLOGY | 1979年 / 50卷 / 02期

关键词：

D O I：

10.1097/00000542-197902000-00009

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Other investigators have demonstrated halothane-induced hepatic injury in rats anesthetized in hypoxic environments. This phenomenon was examined in mice and investigated plasma F- levels in mice and rats anesthetized with halothane in 40, 21, and 7% per cent O2 with or without pretreatment with phenobarbitol or CCl4. No hepatic necrosis was found in mice. Mice produced less F- than rats. This difference in halothane metabolism between Sprague-Dawley rats and Swiss-Webster mice may explain the failure to observe hepatic necrosis in mice.

引用

页码：123 / 125

页数：3