BRAIN DISTRIBUTION OF PROPRANOLOL IN THE RAT

被引：23

作者：

ELGHOZI, JL ^{[1
]}

BIANCHETTI, G ^{[1
]}

MORSELLI, PL ^{[1
]}

MEYER, P ^{[1
]}

机构：

[1] LERS SYNTHELABO,DEPT RECH CLIN,PHARMACOCINET GRP,F-75013 PARIS,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 55卷 / 03期

关键词：

Brain; D; L-Propranolol; Pharmacokinetics; Rat;

D O I：

10.1016/0014-2999(79)90201-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The distribution and kinetics of D,L-propranolol in rat brain were examined after an intravenous injection of the drug. Measurements in brain areas and blood were performed by means of a sensitive and specific gas liquid chromatographic method. The disappearance rate in cortical areas paralleled that in blood. However D,L-propranolol decreased at a slower rate in hypothalamic and medullary nuclei. Since propranolol is believed to have central hypotensive effects, its retention by certain central nuclei involved in blood pressure regulation is of interest. © 1979.

引用

页码：319 / 322

页数：4

共 10 条

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