EFFICACY OF ACYCLOGUANOSINE AGAINST HERPETIC ULCERS IN RABBIT CORNEA

被引:27
作者
SHIOTA, H
INOUE, S
YAMANE, S
机构
[1] Department of Ophthalmology, Tokushima University School of Medicine, Tokushima City 770, Kuramoto-cho
关键词
D O I
10.1136/bjo.63.6.425
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
The effect of a new antiherpetic compound of very low toxicity called acycloguanosine (Wellcome 248U) on herpetic ulcers in rabbit cornea was studied by the Corneal Epithelial Lesion Therapeutic Assay (CELTA). The therapeutic effect of 3 % acycloguanosine ointment on dendritic ulcers was equal to that of 0.5% 5-iodo-2′-deoxyuridine (IDU) ointment. No toxic symptoms could be detected by slit-lamp on 4 days' treatment with this concentration of acycloguanosine. Because of its selective action on virus only, its extremely low toxicity in animals, and its availability for systemic administration, acycloguanosine seems to be an ideal antiviral compound for use in the treatment not only of herpetic keratitis but also of other herpetic diseases in man.
引用
收藏
页码:425 / 428
页数:4
相关论文
共 13 条
  • [1] KERATOMYCOSIS IN WISCONSIN
    CHIN, GN
    HYNDIUK, RA
    KWASNY, GP
    SCHULTZ, RO
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 1975, 79 (01) : 121 - 125
  • [2] SELECTIVITY OF ACTION OF AN ANTI-HERPETIC AGENT, 9-(2-HYDROXYETHOXYMETHYL)GUANINE
    ELION, GB
    FURMAN, PA
    FYFE, JA
    DEMIRANDA, P
    BEAUCHAMP, L
    SCHAEFFER, HJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5716 - 5720
  • [3] HERPES-SIMPLEX KERATITIS - ANIMAL-MODELS TO GUIDE SELECTION AND OPTIMAL DELIVERY OF ANTIVIRAL CHEMOTHERAPY
    FALCON, MG
    JONES, BR
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1977, 3 : 83 - &
  • [4] JONES B R, 1963, Trans Ophthalmol Soc U K, V83, P613
  • [5] JONES BR, 1967, INFLAMMATION, P143
  • [6] KAUFMAN HE, 1978, INVEST OPHTH VIS SCI, V17, P941
  • [7] KAUFMAN HE, 1962, ARCH OPHTHALMOL-CHIC, V67, P583
  • [8] MCGILL J, 1974, T OPHTHAL SOC UK, V94, P342
  • [9] DOUBLE-BLIND CLINICAL STUDY OF ADENINE ARABINOSIDE THERAPY OF VIRAL KERATOCONJUNCTIVITIS
    PAVANLANGSTON, D
    DOHLMAN, CH
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 1972, 74 (01) : 81 - +
  • [10] ACYCLIC ANTI-METABOLITE THERAPY OF EXPERIMENTAL HERPES-SIMPLEX KERATITIS
    PAVANLANGSTON, D
    CAMPBELL, R
    LASS, J
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 1978, 86 (05) : 618 - 623