MORPHOLOGICAL-STUDY OF THE CAPSULAR ORGANIZATION AROUND TISSUE EXPANDERS COATED WITH N-CARBOXYBUTYL CHITOSAN

被引：17

作者：

BIAGINI, G ^{[1
]}

PUGNALONI, A ^{[1
]}

DAMADEI, A ^{[1
]}

BERTANI, A ^{[1
]}

BELLIGOLLI, A ^{[1
]}

BICCHIEGA, V ^{[1
]}

MUZZARELLI, R ^{[1
]}

机构：

[1] UNIV ANCONA,FAC MED & CHIRURG,I-60100 ANCONA,ITALY

来源：

BIOMATERIALS | 1991年 / 12卷 / 03期

关键词：

CHITOSAN; TISSUE REGENERATION; ANGIOGENESIS;

D O I：

10.1016/0142-9612(91)90036-A

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.

引用

页码：287 / 291

页数：5

共 26 条

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