NERVE-TERMINAL EXCITABILITY AND NEUROMUSCULAR-TRANSMISSION IN T(X, Y)V7 AND SHAKER MUTANTS OF DROSOPHILA-MELANOGASTER

被引：46

作者：

MALLART, A ^{[1
]}

ANGAUTPETIT, D ^{[1
]}

BOURRETPOULAIN, C ^{[1
]}

FERRUS, A ^{[1
]}

机构：

[1] INST CAJAL,E-28002 MADRID,SPAIN

来源：

JOURNAL OF NEUROGENETICS | 1991年 / 7卷 / 2-3期

关键词：

SHAKER MUTANTS; SHAKER LOCUS TRANSLOCATION; LARVAL NEUROMUSCULAR JUNCTION; MEMBRANE HYPEREXCITABILITY; TYPE-A POTASSIUM CHANNELS; POTASSIUM CHANNELS; CHANNEL MODULATION; PRESYNAPTIC CURRENTS;

D O I：

10.3109/01677069109066212

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We investigated the neuromuscular transmission in relation with genetic neuronal excitability changes in mutants T(X;Y)V7 and ShKS133 of Drosophila. These mutations affect two different genes belonging to the Shaker gene complex which encode different yet functionally related proteins. Experiments were performed on neuromuscular junctions from Drosophila larvae by recording pre- and postsynatic membrane currents using external electrodes. It was found that the neuromuscular electrophysiological phenotype of T(X;Y)V7 is caused by presynaptic membrane hyperexcitability probably in relation with a Ca2+-dependent down regulation of voltage dependent K channels. By contrast, the ShKS133 phenotype can be explained solely by action potential widening due to the absence of type-A K channels. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：75 / 84

页数：10

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