HOMEODOMAIN BINDING-SITES IN THE 5' FLANKING REGION OF THE BOMBYX-MORI SILK FIBROIN LIGHT-CHAIN GENE

被引:17
作者
HUI, CC [1 ]
SUZUKI, Y [1 ]
KIKUCHI, Y [1 ]
MIZUNO, S [1 ]
机构
[1] TOHOKU UNIV,FAC AGR,DEPT AGR CHEM,SENDAI 981,JAPAN
关键词
D O I
10.1016/S0022-2836(05)80201-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Multiple A + T-rich stretches in the 5′ flanking region of the Bombyx mori fibroin light-chain gene have been shown to bind two Drosophila homeodomain proteins, EVE (even-skipped) and ZEN (zerknüllt), with high affinities. Some of these sites fall into a class that has the established consensus sequence of the binding sites (TCAATTAAAT) for a diverse group of Drosophila homeodomain proteins, while others are quite heterogeneous except that they all possess a core TAAT motif. Since clusters of homeodomain binding sites can also be found in the promoters of other silk protein genes, the fibroin gene and the sericin-1 gene, these observations suggest a possible involvement of some homeobox genes in the regulation of a group of silk protein genes. © 1990 Academic Press Limited.
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页码:395 / 398
页数:4
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