A SINGLE VACCINATION WITH AN INACTIVATED HEPATITIS-A LIPOSOME VACCINE INDUCES PROTECTIVE ANTIBODIES AFTER ONLY 2 WEEKS

被引：53

作者：

JUST, M ^{[1
]}

BERGER, R ^{[1
]}

DRECHSLER, H ^{[1
]}

BRANTSCHEN, S ^{[1
]}

GLUCK, R ^{[1
]}

机构：

[1] SWISS SERUM & VACCINE INST,BERN,SWITZERLAND

来源：

VACCINE | 1992年 / 10卷 / 11期

关键词：

HEPATITIS-A; ONE-DOSE REGIMEN; ADJUVANT; LIPOSOMES;

D O I：

10.1016/0264-410X(92)90506-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the near future an inactivated hepatitis A vaccine will be commercially available. The recommended vaccination schedule will include at least two vaccinations 1 month apart. Giving two doses of vaccine on the same day in one injection results in protection after 2-4 weeks dependent on the adjuvant used. Hepatitis A virus incorporated into liposomes proved to be a suitable formulation in term of rapid seroconversion, high level of mean antibody content and low reactogenicity.

引用

页码：737 / 739

页数：3

共 10 条

[1]

FLEHMIG B, 1989, LANCET, V1, P1039

[2]

GARCON NMJ, 1991, J IMMUNOL, V146, P3697

[3]

GLUCK R, 1992, IN PRESS INT TRAVEL

[4]

HESS G, 1990, INTERSCI C ANTIMICRO, V30, P147

[5]

JUST M, 1989, INTERSCIENCE C ANTIM, V29, P196

[6]

JUST M, 1989, SCHWEIZ MED WOCH S28, V119, P27

[7] IMMUNOGENICITY OF AN INACTIVATED HEPATITIS-A VACCINE [J].

SJOGREN, MH ;

HOKE, CH ;

BINN, LN ;

ECKELS, KH ;

DUBOIS, DR ;

TSUCHIDA, A ;

OAKS, S ;

MARCHWICKI, R ;

LEDNAR, W ;

CHLOUPEK, R ;

TICEHURST, J ;

BANCROFT, WH .

ANNALS OF INTERNAL MEDICINE, 1991, 114 (06) :470-471

[8] HEALTH-PROBLEMS AFTER TRAVEL TO DEVELOPING-COUNTRIES [J].

STEFFEN, R ;

RICKENBACH, M ;

WILHELM, U ;

HELMINGER, A ;

SCHAR, M .

JOURNAL OF INFECTIOUS DISEASES, 1987, 156 (01) :84-91

[9] LIPOSOMAL VACCINE - INFLUENCE OF ANTIGEN ASSOCIATION ON THE KINETICS OF THE HUMORAL RESPONSE [J].

THERIEN, HM ;

LAIR, D ;

SHAHUM, E .

VACCINE, 1990, 8 (06) :558-562

[10] SAFETY AND IMMUNOGENICITY OF AN INACTIVATED HEPATITIS-A CANDIDATE VACCINE IN HEALTHY ADULT VOLUNTEERS [J].

WIEDERMANN, G ;

AMBROSCH, F ;

KOLLARITSCH, H ;

HOFMANN, H ;

KUNZ, C ;

DHONDT, E ;

DELEM, A ;

ANDRE, FE ;

SAFARY, A ;

STEPHENNE, J .

VACCINE, 1990, 8 (06) :581-584

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