SYNTHESIS OF 1-(2-AMINOPROPYL)BENZIMIDAZOLES, STRUCTURALLY RELATED TO THE TIBO DERIVATIVE R82150, WITH ACTIVITY AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS

被引：14

作者：

SWAYZE, EE

PEIRIS, SM

KUCERA, LS

WHITE, EL

WISE, DS

DRACH, JC

TOWNSEND, LB

机构：

[1] UNIV MICHIGAN,COLL LITERATURE SCI & ARTS,DEPT CHEM,ANN ARBOR,MI 48109

[2] SO RES INST,MICROBIOL RES DEPT,BIRMINGHAM,AL 35205

[3] UNIV MICHIGAN,COLL PHARM,DEPT MED CHEM,ANN ARBOR,MI 48109

[4] UNIV MICHIGAN,SCH DENT,DEPT BIOL & MAT SCI,ANN ARBOR,MI 48109

[5] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT MICROBIOL & IMMUNOL,WINSTON SALEM,NC 27103

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81224-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of 1-(2-aminopropyl)-2-mercaptobenzimidazoles related to the TIBO derivative R82150 have been prepared and tested for their activity against human immunodeficiency virus type 1 (HIV-1). These compounds were all modest inhibitors of the cytopathic effects of HIV-1 in vitro, but only very weak inhibitors of HIV-1 reverse transcriptase (RT).

引用

页码：543 / 546

页数：4

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