A HUMAN PROMYELOCYTE MESSENGER-RNA TRANSIENTLY INDUCED BY TPA IS HOMOLOGOUS TO YEAST IPP ISOMERASE

被引：27

作者：

XUAN, JW

KOWALSKI, J

CHAMBERS, AF

DENHARDT, DT

机构：

[1] UNIV WESTERN ONTARIO,DEPT ONCOL,LONDON N6A 4L6,ON,CANADA

[2] LONDON REG CANC CTR,LONDON N6A 4L6,ON,CANADA

来源：

GENOMICS | 1994年 / 20卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1139

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A cDNA clone was isolated from HL60 human promyelocyte cells on the basis of the induction of its cognate mRNA by the phorbol ester TPA (12-O-tetradecanoyl phorbol-13-acetate) in the presence of cycloheximide. Northern analysis showed a peak of induction of a 1.9-kb mRNA at 3-6 h after TPA addition. Sequence analysis revealed that this cDNA was likely a human homolog of yeast isopentenyl diphosphate:dimethylallyl diphosphate isomerase, an enzyme important for isoprenoid synthesis and the prenylation of proteins such as res p21. (C) 1994 Academic Press, Inc.

引用

页码：129 / 131

页数：3

共 14 条

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