Hereditary renal cell carcinoma in the Eker rat: A unique animal model for the study of cancer susceptibility

被引：24

作者：

Everitt, JI ^{[1
]}

Goldsworthy, TL ^{[1
]}

Wolf, DC ^{[1
]}

Walker, CL ^{[1
]}

机构：

[1] MD ANDERSON CANC CTR, DEPT CARCINOGENESIS, SMITHVILLE, TX USA

来源：

TOXICOLOGY LETTERS | 1995年 / 82-3卷

关键词：

renal carcinoma; suppressor gene; cancer susceptibility;

D O I：

10.1016/0378-4274(95)03506-0

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

A class of genes, the so-called tumor suppressor genes or anti-oncogenes, was originally identified as being responsible for germ-line transmission of cancer susceptibility in humans, Tumor suppressor genes are recessive at the cellular level with respect to oncogenesis but often manifest as dominantly inherited familial cancer syndromes, This type of cancer syndrome arises in the Eker rat due to a genetic defect in the tuberous sclerosis 2 (Tsc2) gene. The Eker rat familial cancer syndrome serves as a unique animal model in which to study the molecular pathways of renal tubular epithelial carcinogenesis as well as a valuable tool for studies that examine how chemical carcinogens interact with cancer susceptibility genes.

引用

页码：621 / 625

页数：5

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