AMYLOID BETA-PEPTIDE IN CEREBROSPINAL-FLUID IN INDIVIDUALS WITH THE SWEDISH ALZHEIMER AMYLOID PRECURSOR PROTEIN MUTATION

被引：31

作者：

LANNFELT, L ^{[1
]}

BASUN, H ^{[1
]}

VIGOPELFREY, C ^{[1
]}

WAHLUND, LO ^{[1
]}

WINBLAD, B ^{[1
]}

LIEBERBURG, I ^{[1
]}

SCHENK, D ^{[1
]}

机构：

[1] ATHENA NEUROSCI INC,S SAN FRANCISCO,CA 94080

来源：

NEUROSCIENCE LETTERS | 1995年 / 199卷 / 03期

关键词：

ALZHEIMERS DISEASE; AMYLOID BETA-PEPTIDE; AMYLOID PRECURSOR PROTEIN; PATHOGENIC MUTATION; CEREBROSPINAL FLUID;

D O I：

10.1016/0304-3940(95)12059-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuropathological hallmarks of Alzheimer's disease (AD) are amyloid-containing plaques and neurofibrillary tangles. The main constituent of senile plaques is amyloid beta-peptide (A beta) and in recent years, pathogenic mutations in the amyloid precursor protein (APP) gene have been discovered in some AD families. The APP(670/671) mutation, found in a Swedish AD family, has revealed over-production of A beta as one pathogenic mechanism for the development of AD. In the present study we have used an immunoassay to measure A beta levels in cerebrospinal fluid (CSF) from APP(670/671) mutation-carriers and non-carriers. A correlation was seen between decrease in A beta levels and duration of disease although no difference was found in levels of A beta between the groups (14.5 +/- 3.3 ng/ml versus 14.9 +/- 2.3 ng/ml).

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收藏

页码：203 / 206

页数：4

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