COMPARATIVE CARDIOTOXICITY AND ANTITUMOR-ACTIVITY OF DOXORUBICIN (ADRIAMYCIN) AND 4'-DEOXYDOXORUBICIN AND THE RELATIONSHIP TO INVIVO DISPOSITION AND METABOLISM IN THE TARGET TISSUES

被引：23

作者：

CUMMINGS, J

WILLMOTT, N

MORE, I

KERR, DJ

MORRISON, JG

KAYE, SB

机构：

[1] UNIV STRATHCLYDE,DEPT PHARM,GLASGOW G1 1XW,SCOTLAND

[2] UNIV GLASGOW,DEPT MED ONCOL,GLASGOW G12 9LX,SCOTLAND

[3] WESTERN INFIRM,DEPT PATHOL,GLASGOW G12,SCOTLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1987年 / 36卷 / 09期

关键词：

D O I：

10.1016/0006-2952(87)90120-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：1521 / 1526

页数：6

共 39 条

[1] NADPH CYTOCHROME-P-450 REDUCTASE ACTIVATION OF QUINONE ANTI-CANCER AGENTS TO FREE-RADICALS [J].

BACHUR, NR ;

GORDON, SL ;

GEE, MV ;

KON, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (02) :954-957

[2]

BACHUR NR, 1977, MOL PHARMACOL, V13, P901

[3]

BACHUR NR, 1978, CANCER RES, V38, P1745

[4] ADRIAMYCIN - NEW ANTICANCER DRUG WITH SIGNIFICANT CLINICAL ACTIVITY [J].

BLUM, RH ;

CARTER, SK .

ANNALS OF INTERNAL MEDICINE, 1974, 80 (02) :249-259

[5] THE CARDIOTOXIC ANTIBIOTIC DOXORUBICIN INHIBITS THE NA+-CA-2+ EXCHANGE OF DOG HEART SARCOLEMMAL VESICLES [J].

CARONI, P ;

VILLANI, F ;

CARAFOLI, E .

FEBS LETTERS, 1981, 130 (02) :184-186

[6]

CASAZZA AM, 1979, CANCER TREAT REP, V63, P835

[7] DETERMINATION OF ADRIAMYCIN, ADRIAMYCINOL AND THEIR 7-DEOXYAGLYCONES IN HUMAN-SERUM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

CUMMINGS, J ;

STUART, JFB ;

CALMAN, KC .

JOURNAL OF CHROMATOGRAPHY, 1984, 311 (01) :125-133

[8] METHOD FOR THE DETERMINATION OF 4'-DEOXYDOXORUBICIN, 4'-DEOXYDOXORUBICINOL AND THEIR 7-DEOXYAGLYCONES IN HUMAN-SERUM BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

CUMMINGS, J .

JOURNAL OF CHROMATOGRAPHY, 1985, 341 (02) :401-409

[9] MARKED INTER-PATIENT VARIATION IN ADRIAMYCIN BIOTRANSFORMATION TO 7-DEOXYAGLYCONES - EVIDENCE FROM METABOLITES IDENTIFIED IN SERUM [J].

CUMMINGS, J ;

MILSTEAD, R ;

CUNNINGHAM, D ;

KAYE, S .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1986, 22 (08) :991-1001

[10] DISPOSITION KINETICS OF ADRIAMYCIN, ADRIAMYCINOL AND THEIR 7-DEOXYAGLYCONES IN AKR MICE BEARING A SUB-CUTANEOUSLY GROWING RIDGWAY OSTEOGENIC-SARCOMA (ROS) [J].

CUMMINGS, J ;

MERRY, S ;

WILLMOTT, N .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1986, 22 (04) :451-460

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