EFFECTS OF TAURINE, GLYCINE AND GABA ON CONVULSIONS PRODUCED BY STRYCHNINE IN THE RABBIT

被引:8
作者
ROCHES, JC [1 ]
ZUMSTEIN, HR [1 ]
FASSLER, A [1 ]
SCOLLOLAVIZZARI, G [1 ]
HOSLI, L [1 ]
机构
[1] UNIV BASEL,NEUROL CLIN,ELECTROENCEPHALOG LAB,CH-4051 BASEL,SWITZERLAND
关键词
D O I
10.1159/000115050
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The action of intravenously injected taurine, glycine and GABA has been tested on convulsions induced by strychnine using electroencephalographic and electromyographic recordings. The dose of strychnine necessary to produce a generalized tonic-clonic seizure was 0.55 ± 0.15 mg/kg intravenously for rabbits pretreated with taurine, which was significantly higher than for control animals (0.38 ± 0.13 mg/kg). After pretreatment with glycine, the strychnine dose required to evoke convulsions (0.51 ± 0.22 mg/kg) was also higher than the control values, but the difference was statistically not significant. The convulsive dose of strychnine in animals pretreated with GABA was slightly but not significantly lower than in control animals (0.31 ± 0.13 mg/kg). These results suggest that taurine is the most effective amino acid to protect rabbits from seizures induced by strychnine.
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页码:26 / 32
页数:7
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