RECEPTORS IN DISEASE - AN OVERVIEW

被引:1
作者
AMINO, N
机构
[1] Department of Laboratory Medicine, Osaka University Medical School, Osaka
关键词
anti-TSH receptor antibodies; G proteins; N proteins; PHP type I; receptor-; receptor-related abnormalities; signal transduction;
D O I
10.1016/0009-9120(90)90381-4
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Hormones and certain other signal molecules bind to plasma membrane or intracellular receptors producing signals that initiate their physiological effects. Recent understanding of receptors has resulted in recognition of several categories of receptor-related abnormalities. (a) Congenital receptor abnormalities such as receptor deficiency syndrome. LDL receptor defect in familial hypercholesteremia and primary androgen resistance are examples. (b) Postreceptor coupling abnormalities such as pseudohypoparathyroidism type 1a where there are reduced levels of guanine nucleotide receptor cyclase coupling protein. (c) Acquired receptor abnormalities, such as presence of circulating antireceptor antibodies. Such antibodies have been implicated in the pathophysiology of many diseases including Graves' disease and myasthenia gravis. © 1990 The Canadian Society of Clinical Chemists.
引用
收藏
页码:31 / 36
页数:6
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