EFFECTS OF ANGIOTENSIN-II ON PHOSPHATIDYLINOSITIDE HYDROLYSIS IN RAT-BRAIN

被引：14

作者：

TAMURA, CS

SPETH, RC

机构：

[1] WASHINGTON STATE UNIV, DEPT VET & COMPARAT ANAT PHARMACOL & PHYSIOL, PULLMAN, WA 99164 USA

[2] WASHINGTON STATE UNIV, DEPT PHARMACOL TOXICOL, PULLMAN, WA 99164 USA

来源：

NEUROCHEMISTRY INTERNATIONAL | 1990年 / 17卷 / 03期

关键词：

D O I：

10.1016/0197-0186(90)90030-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiotensin II has been coupled to the hydrolysis of phosphatidylinositide in various peripheral tissues; however, little is yet known about its association in the central nervous system. Intracellular phosphatidylinositide was prelabeled by incubation with [3H]myo-inositol and the rate of hydrolysis determined by monitoring the rate of formation of [3H]inositol monophosphate. In hypothalamus, thalamus, septum and midbrain tissues, angiotensin II reduced the formation of [3H]inositol monophosphate and this effect was partially reversed by the presence of an angiotensin II antagonist, sarcosine, isoleucine angiotensin II. These data suggest that angiotensin II receptor stimulation may inhibit the hydrolysis of phosphatidylinositide in the brain. © 1990.

引用

页码：475 / 479

页数：5

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