REVERSAL OF THE INTERFERON-INDUCED BLOCK OF PROTEIN-SYNTHESIS BY PURIFIED PREPARATIONS OF EUKARYOTIC INITIATION FACTOR-2

被引：20

作者：

KAEMPFER, R ^{[1
]}

ISRAELI, R ^{[1
]}

ROSEN, H ^{[1
]}

KNOLLER, S ^{[1
]}

ZILBERSTEIN, A ^{[1
]}

SCHMIDT, A ^{[1
]}

REVEL, M ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT VIROL,REHOVOT 76100,ISRAEL

来源：

VIROLOGY | 1979年 / 99卷 / 01期

关键词：

D O I：

10.1016/0042-6822(79)90049-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The translation of Mengo virus RNA in extracts of interferon-treated mouse L cells in the presence of double-stranded RNA is inhibited about 80% when compared to translation in control cell extracts. Addition of eucaryotic initiation factor 2 (eIF-2) purified from rabbit reticulocytes leads to effective reversal of the interferon-induced block. This finding suggests that in interferon-treated cell extracts, inactivation of eIF-2 is a major mechanism of translational control. © 1979.

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页码：170 / 173

页数：4

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