MODELING AIDS VACCINES - THE CELLULAR-LEVEL

被引：2

作者：

STRUCHINER, CJ ^{[1
]}

HALLORAN, ME ^{[1
]}

机构：

[1] EMORY UNIV,SCH PUBL HLTH,DIV BIOSTAT,ATLANTA,GA 30329

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 1992年 / 87卷 / 01期

关键词：

AIDS VACCINES; VACCINE MODELS;

D O I：

10.1590/S0074-02761992000100017

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

This paper discusses current strategies for the development of AIDS vaccines which allow immunization to disturb the natural course of HIV at different detailed stages of its life cycle. Mathematical models describing the main biological phenomena (i.e. virus and vaccine induced T4 cell growth; virus and vaccine induced activation of latently infected T4 cells; incremental changes in immune response as infection progresses, antibody dependent enhancement and neutralization of infection) and allowing for different vaccination strategies serve as a background for computer simulations. The mathematical models reproduce updated information on the behavior of immune cells, antibody concentrations and free viruses, The results point to some controversial outcomes of an AIDS vaccine such as an early increase in virus concentration among vaccinated when compared to nonvaccinated individuals.

引用

页码：103 / 113

页数：11

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