SYNTHESIS OF, AND LACK OF INHIBITION OF A RHAMNOSIDASE BY, BOTH ENANTIOMERS OF DEOXYRHAMNOJIRIMYCIN AND RHAMNONOLACTAM - BETA-MANNOSIDASE INHIBITION BY DELTA-LACTAMS

被引：56

作者：

FAIRBANKS, AJ

CARPENTER, NC

FLEET, GWJ

RAMSDEN, NG

DEBELLO, IC

WINCHESTER, BG

ALDAHER, SS

NAGAHASHI, G

机构：

[1] UNIV LONDON,INST CHILD HLTH,DIV BIOCHEM S METAB,LONDON WC1N 1EH,ENGLAND

[2] USDA ARS,EASTERN REG RES CTR,PHILADELPHIA,PA 19118

来源：

TETRAHEDRON | 1992年 / 48卷 / 16期

关键词：

D O I：

10.1016/0040-4020(92)85012-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of both enantiomers of deoxyrhamnojirimycin and rhamnonolactam from D- and L-gulonolactones are described. The effects as inhibitors of the enantiomeric deoxyrhamnojirimycins and rhamnonolactams on human liver glycosidases are compared with deoxymannojirimycin and mannonolactam. No significant inhibition of the activity of naringinase (an alpha-L-rhamnosidase) was caused by any of these compounds.

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收藏

页码：3365 / 3376

页数：12

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