BIOMIMETIC SYNTHESIS OF THE CENTRAL TRICYCLIC PORTION OF PTILOMYCALIN-A

被引：29

作者：

SNIDER, BB

SHI, ZP

机构：

[1] Department of Chemistry Brandeis University, Waltham, MA 02254

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(00)60355-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The central tricyclic portion 20 of ptilomycalin A (1) is formed from bis enone 16 in two steps. Addition of O-methylisourea in DMF to 16 affords a mixture of 17 and 18 that are both converted to a single tricyclic aminal 20a on treatment with NH3 and NH4OAc in methanol at reflux.

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页码：2099 / 2102

页数：4

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