EARLY CYTOKINE RESPONSE TO MULTIPLE INJURY

被引：31

作者：

FOEX, BA

LAMB, WR

ROBERTS, TE

BREAR, SG

MACARTNEY, I

HAMMER, M

BRENCHLEY, PEC

机构：

[1] Department of Intensive Care, North Manchester General Hospital, Manchester

[2] Department of Biochemistry, North Manchester General Hospital, Manchester

[3] Department of Immunology, St Mary's Hospital, Manchester

来源：

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 1993年 / 24卷 / 06期

关键词：

D O I：

10.1016/0020-1383(93)90098-Q

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Serial measurements of the inflammatory cytokines interleukin 6 (IL-6) and tumour necrosis factor alpha (TNFalpha) were made in four patients with multiple injuries to characterize secretion patterns and to relate them to severity of injury and degree of haemorrhage. IL-6 and TNFalpha were assayed using a sandwich ELISA. Injury scores varied from 9 to 50, and transfusion requirements varied from 7 to 14 units. All patients showed an increase in IL-6 but only one a rise in TFNalpha. There was no consistent pattern in the elevation of IL-6 and there was no relation between cytokine levels, severity of injury, transfusion requirement or ultimate outcome. From this preliminary study it would seem that measurement of IL-6 and TNFalpha is not of value in directing therapeutic decisions or as a predictor of outcome.

引用

页码：373 / 376

页数：4

共 18 条

[1]

Ayala, Perrin, Meldrum, Et al., Haemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin, Cytokine, 2, (1990)

[2]

Ayala, Wang, Zheng, Et al., Differential alterations in plasma IL-6 and TNF levels after trauma and haemorrhage, Am. J. Physiol., 260, (1991)

[3]

Baker, O'Neill, Haddon, Et al., The ‘injury severity score’: a method for describing patients with multiple injuries and evaluating emergency care, J. Trauma, 14, (1974)

[4]

Beutler, Greenwald, Hulmes, Et al., Identity of tumor necrosis factor and the macrophage-secreted factor cachectin, Nature, 316, (1985)

[5]

Beutler, Cerami, Cachectin: more than a tumor necrosis factor, N. Engl. J. Med., 316, (1987)

[6]

Damas, Reuter, Gysen, Et al., Tumour necrosis factor and interleukin-1: serum levels during severe sepsis in humans, Crit. Care Med., 17, (1989)

[7]

Debets, Kampmeijer, van der Linden, Et al., Plasma tumour necrosis factor and mortality in critically ill septic patients, Crit. Care Med., 17, (1989)

[8]

Di Padova, Pozzi, Tondre, Et al., Selective and early increase of IL-1 inhibitotrs, IL-6 and cortisol after elective surgery, Clin. Exp. Med., 85, (1991)

[9]

Emery, Salmon, Et al., Systemic mediators of inflammation, Br. J. Hosp. Med., 45, (1991)

[10]

Hack, DeGroot, Felt-Bersma, Et al., Increased plasma levels of interleukin-6 in sepsis, Blood, 74, (1989)

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