MERCAPTOACYL DIPEPTIDES AS DUAL INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE - PRELIMINARY STRUCTURE-ACTIVITY STUDIES

被引：36

作者：

DELANEY, NG ^{[1
]}

BARRISH, JC ^{[1
]}

NEUBECK, R ^{[1
]}

NATARAJAN, S ^{[1
]}

COHEN, M ^{[1
]}

ROVNYAK, GC ^{[1
]}

HUBER, G ^{[1
]}

MURUGESAN, N ^{[1
]}

GIROTRA, R ^{[1
]}

SIEBERMCMASTER, E ^{[1
]}

ROBL, JA ^{[1
]}

ASAAD, MM ^{[1
]}

CHEUNG, HS ^{[1
]}

BIRD, JE ^{[1
]}

WALDRON, T ^{[1
]}

PETRILLO, EW ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB CO,PHARMACEUT RES INST,PRINCETON,NJ 08543

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)80371-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mercaptoacyl dipeptides were prepared as dual-acting ACE/NEP inhibitors. Inhibition of each enzyme may be explained by different binding models. Structure-activity studies determined that, in this series of compounds, the mercaptopropanoyl dipeptide framework leads to increased affinity for NEP but diminished ACE activity in vivo.

引用

页码：1783 / 1788

页数：6

共 37 条

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