RAPID REVERSIBLE PHOSPHORYLATION OF RAT-BRAIN TAU PROTEINS IN RESPONSE TO COLD-WATER STRESS

被引：49

作者：

KORNEYEV, A ^{[1
]}

BINDER, L ^{[1
]}

BERNARDIS, J ^{[1
]}

机构：

[1] MOLEC GERIATR CORP,LAKE BLUFF,IL 60040

来源：

NEUROSCIENCE LETTERS | 1995年 / 191卷 / 1-2期

关键词：

STRESS; TAU PROTEIN; HYPOTHALAMIC-PITUITARY-ADRENAL AXIS; ALZHEIMERS DISEASE; MICROTUBULES; PROTEIN PHOSPHORYLATION;

D O I：

10.1016/0304-3940(95)11546-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of cold water stress (CWS) on the phosphorylation of tau proteins in rat brain was studied using monoclonal antibodies to phosphorylated (PHF-1) and non-phosphorylated (TAU-1) epitopes. CWS induced an immediate 2-3-fold increase of PHF-I signal in the soluble fraction of rat brain cortex, hippocampus and cerebellum. A maximal 3-4-fold increase occurred in 30-90 min. The soluble TAU-1 signal decreased following the CWS and at 60 min became significantly lower (P < 0.05) than in the control. Both signals returned to the normal range within 3 h. CWS induced a similar increase in PHF-I signal in adrenalectomized animals and in animals subchronically treated with cortisone. These data indicate that stress induces rapid phosphorylation of soluble rat brain tau without direct involvement of the hypothalamic-pituitary-adrenal axis.

引用

页码：19 / 22

页数：4

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[2]

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