ACTION OF TETRODOTOXIN ON FROGS ISOLATED MUSCLE SPINDLE

被引:12
作者
ALBUQUER.EX
CHUNG, SH
OTTOSON, D
机构
[1] Department of Physiology, Royal Veterinary College, Stockholm
来源
ACTA PHYSIOLOGICA SCANDINAVICA | 1969年 / 75卷 / 03期
关键词
D O I
10.1111/j.1748-1716.1969.tb04383.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Tetrodotoxin in concentrations of 0.8–1.0 × 10‐7 g/ml completely blocked conducted activity of the afferent nerve of isolated frog muscle spindle without affecting the receptor potential. Development of block was characterized by an increase in threshold of the nerve, a gradual delay of the onset of the impulse response and a reduction and decomposition of the individual action potentials into smaller spikes. The spike decomposition appeared to be due to a de‐synchronization of the conducted activity in the branched afferent terminals. After block by tetrodotoxin for up to 20 min the normal response could be restored by washing the preparation with Ringer's solution. The blocking action of tetrodotoxin was delayed and reduced by increasing calcium; removal of calcium had the opposite effect. Tetrodotoxin (1000 ng/ml) had no significant effect on the receptor potential. With low sodium plus tetrodotoxin the receptor potential was reduced by about 50 %; this reduction was reversed by addition of normal sodium. It is suggested that the sodium carrying system of the generator potential differs from that underlying the regenerative activity. © 1969 Scandinavian Physiological Society
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页码:301 / &
相关论文
共 27 条
[1]   THE EFFECT OF INTERNAL AND EXTERNAL POTASSIUM CONCENTRATION ON THE MEMBRANE POTENTIAL OF FROG MUSCLE [J].
ADRIAN, RH .
JOURNAL OF PHYSIOLOGY-LONDON, 1956, 133 (03) :631-658
[2]   EFFECTS OF TETRODOTOXIN ON SLOWLY ADAPTING STRETCH RECEPTOR NEURONE OF LOBSTER [J].
ALBUQUERQUE, EX ;
GRAMPP, W .
JOURNAL OF PHYSIOLOGY-LONDON, 1968, 195 (01) :141-+
[3]  
ALBUQUERQUE EX, 1968, ACTA PHYSIOL SCAND, V72, P301
[4]   THE RELATION BETWEEN RECEPTOR POTENTIALS AND THE CONCENTRATION OF SODIUM IONS [J].
DIAMOND, J ;
GRAY, JAB ;
INMAN, DR .
JOURNAL OF PHYSIOLOGY-LONDON, 1958, 142 (02) :382-394
[5]   THE EFFECT OF CALCIUM ON THE MYELINATED NERVE FIBRE [J].
FRANKENHAEUSER, B .
JOURNAL OF PHYSIOLOGY-LONDON, 1957, 137 (02) :245-260
[6]  
FRANKENHAEUSER B, 1957, J PHYSL, V137, P217
[7]  
HAAPANEN LE, 1962, ELECTRON ENG, V34, P183
[8]  
KAO CY, 1966, PHARMACOL REV, V18, P997
[9]   CELLULAR ORGANIZATION OF FROG MUSCLE SPINDLE AS REVEALED BY SERIAL SECTIONS FOR ELECTRON MICROSCOPY [J].
KARLSSON, U ;
ANDERSSO.E ;
OTTOSON, D .
JOURNAL OF ULTRASTRUCTURE RESEARCH, 1966, 14 (1-2) :1-&
[10]   ACTION POTENTIALS FROM A SENSORY NERVE ENDING [J].
KATZ, B .
JOURNAL OF PHYSIOLOGY-LONDON, 1950, 111 (3-4) :248-260